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12-29-2008, 07:26 PM
#2 (permalink)
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this is what I found on it.
GLUCOTROL XL: Side effects, ratings, and patient comments
in that link are some other patients comments and reactions.
This is what the drug company says:
In U.S. and foreign controlled studies, the frequency of serious adverse reactions reported was very low. Of 702 patients, 11.8% reported adverse reactions and in only 1.5% was GLUCOTROL discontinued.
Hypoglycemia: See
PRECAUTIONS and
OVERDOSAGE sections. Gastrointestinal: Gastrointestinal disturbances are the most common reactions. Gastrointestinal complaints were reported with the following approximate incidence:
nausea and
diarrhea, one in seventy; constipation and gastralgia, one in one hundred. They appear to be dose-related and may disappear on division or reduction of dosage. Cholestatic
jaundice may occur rarely with sulfonylureas: GLUCOTROL should be discontinued if this occurs.
Dermatologic: Allergic skin reactions including
erythema, morbilliform or maculopapular eruptions,
urticaria,
pruritus, and
eczema have been reported in about one in seventy patients. These may be transient and may disappear despite continued use of GLUCOTROL; if skin reactions persist, the drug should be discontinued.
Porphyria cutanea tarda and photosensitivity reactions have been reported with sulfonylureas.
Hematologic: Leukopenia,
agranulocytosis, thrombocytopenia,
hemolytic anemia,
aplastic anemia, and
pancytopenia have been reported with sulfonylureas.
Metabolic: Hepatic porphyria and disulfiram-like reactions have been reported with sulfonylureas. In the mouse, GLUCOTROL pretreatment did not cause an accumulation of acetaldehyde after ethanol administration. Clinical experience to date has shown that GLUCOTROL has an extremely low incidence of disulfiram-like alcohol reactions.
Endocrine Reactions: Cases of
hyponatremia and the
syndrome of inappropriate
antidiuretic hormone (SIADH) secretion have been reported with this and other sulfonylureas.
Miscellaneous: Dizziness, drowsiness, and
headache have each been reported in about one in fifty patients treated with GLUCOTROL. They are usually transient and seldom require discontinuance of therapy.
Laboratory Tests: The pattern of laboratory test abnormalities observed with GLUCOTROL was similar to that for other sulfonylureas. Occasional mild to moderate elevations of
SGOT,
LDH,
alkaline phosphatase,
BUN and
creatinine were noted. One case of jaundice was reported. The relationship of these abnormalities to GLUCOTROL is uncertain, and they have rarely been associated with clinical symptoms.
Question about Glucotrol 
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